Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.

doi:10.1038/s41467-021-27706-6

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Article

Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.

Nature communications - 10 Jan 2022

Scholz Markus, Horn Katrin, Pott Janne, Gross Arnd, Kleber Marcus E, Delgado Graciela E, Mishra Pashupati Prasad, Kirsten Holger, Gieger Christian, Müller-Nurasyid Martina, Tönjes Anke, Kovacs Peter, Lehtimäki Terho, Raitakari Olli, Kähönen Mika, Gylling Helena, Baber Ronny, Isermann Berend, Stumvoll Michael, Loeffler Markus, März Winfried, Meitinger Thomas, Peters Annette, Thiery Joachim, Teupser Daniel, Ceglarek Uta

Abstract excerpt

Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially discussed. We perform a genome-wide meta-analysis of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9758 subjects and detect ten independent genome-wide significant SNPs at seven genomic loci....

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PMID: 35013273
DOI: 10.1038/s41467-021-27706-6
PMCID: PMC8748632

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