Article
Yeast sphingolipid bypass mutants as indicators of antifungal agents selectively targeting sphingolipid synthesis.
Biochemical and biophysical research communications - 25 Jul 2003
Nagiec Marek M, Young Casey L, Zaworski Phillip G, Kobayashi Scott D
Abstract excerpt
Standard methods for evaluating the target specificity of antimicrobial agents often involve the use of microorganisms with altered expression of selected targets and thus either more resistant or more susceptible to target specific inhibitors. In this study we present an alternative approach that utilizes physiological bypass mutants. The Saccharomyces cerevisiae sphingolipid bypass mutant strain AGD is able to...
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