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Article

Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae.

Current genetics - 1 Apr 2010

Banuelos M G, Moreno D E, Olson D K, Nguyen Q, Ricarte F, Aguilera-Sandoval C R, Gharakhanian Editte

Abstract excerpt

The vacuole of Saccharomyces cerevisiae has been a seminal model for studies of lysosomal trafficking, biogenesis, and function. Several yeast mutants defective in such vacuolar events have been unable to grow at low levels of hygromycin B, an aminoglycoside antibiotic. We hypothesized that such severe hypersensitivity to hygromycin B (hhy) is linked to vacuolar defects and performed a genomic screen for the...

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Identifiers

PMID: 20043226
DOI: 10.1007/s00294-009-0285-3
PMCID: PMC2886664

Genes

PAF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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