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Article

Plasma proteome mendelian randomization and network pharmacology reveal therapeutic targets for thyroid disorders.

Molecular and cellular endocrinology - 1 May 2026

Wang Chao, Cai Yi, Yang Xing, Jie Jie

Abstract excerpt

INTRODUCTION: Thyroid disorders, including hypothyroidism, hyperthyroidism, and thyroid cancer, impose a substantial global health burden. Existing treatments face limitations due to adverse effects and incomplete efficacy, highlighting the need for innovative therapeutic strategies informed by genetic and molecular insights. METHODS: We integrated Mendelian randomization (MR) with network pharmacology to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 41616832
DOI: 10.1016/j.mce.2026.112752

Genes

RPS6KA6
CDH1
DCP1B
FGF19
IL2RB
PSAPL1
SPRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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