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Article

Novel Causal Plasma Proteins for Hypothyroidism: A Large-scale Plasma Proteome Mendelian Randomization Analysis.

The Journal of clinical endocrinology and metabolism - 17 Jan 2023

Yang Hongqun, Chen Lanlan, Liu Yahui

Abstract excerpt

CONTEXT: Although several risk proteins for hypothyroidism have been reported in recent years, many more plasma proteins have not been tested. OBJECTIVE: To determine potential mechanisms and novel causal plasma proteins for hypothyroidism using Mendelian randomization (MR). METHODS: A large-scale plasma proteome MR analysis was conducted using protein quantitative trait loci (pQTLs) for 2297 plasma proteins. We...

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PMID: 36190832
DOI: 10.1210/clinem/dgac575

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