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Article

Integrative multi-omics Mendelian randomization and functional validation identifies RNASET2 as a novel therapeutic target for autoimmune thyroiditis.

Frontiers in endocrinology - 1 Jan 2026

Jiang Bo, Wang Yanxue, Qu Cheng, Zhang Chen, Jiang Chaoyu, Su Lei, Guan Wenxian, Luo Yuqian

Abstract excerpt

Objective: Autoimmune thyroiditis (AIT), a prevalent autoimmune disorder that frequently leads to hypothyroidism. A critical unmet need exists for disease-modifying therapies that target its underlying pathogenesis. This study aimed to identify and validate novel therapeutic targets for AIT. Methods: We employed an integrative genomics approach, combining genome-wide association studies (GWAS) with molecular...

Topics

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Genome-Wide Association Study
Mendelian Randomization Analysis
Multiomics
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroiditis, Autoimmune

Tumor Suppressor Proteins

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Open in PubMed Open full text

Identifiers

PMID: 41704487
DOI: 10.3389/fendo.2026.1715937
PMCID: PMC12907157

Genes

RNASET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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