Article

Identification of therapeutic targets for 18 clinical diseases by integrating human plasma proteome with genome

2023-10-23

Abstract excerpt

The proteome is an abundant source of potential therapeutic targets, and a comprehensive evaluation of proteins as therapeutic targets for a wide range of diseases is required. By screening 4,907 plasma proteins, we conducted a systematically two-sample proteome-wide Mendelian randomisation (MR) study to uncover potential therapeutic targets for 18 clinical diseases. Following MR analysis and stringent process fil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 656ccd9d-dd3f-586f-aada-f41148d26c83
DOI: 10.1101/2023.10.23.23297376

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of therapeutic targets for 18 clinical diseases by integrating human plasma proteome with genomeDOI 10.1101/2023.10.23.23297376Read

Novel Causal Plasma Proteins for Hypothyroidism: A Large-scale Plasma Proteome Mendelian Randomization Analysis.Semantic proximity Read

Plasma proteome mendelian randomization and network pharmacology reveal therapeutic targets for thyroid disorders.Semantic proximity Read

Comprehensive genomic atlas of plasma proteome in the Japanese population: the Nagahama studySemantic proximity Read

Genetic mechanisms of 184 neuro-related proteins in human plasmaSemantic proximity Read

Identification and genetic validation of potential therapeutic targets for pulmonary hypertension through multi-omics causal inference.Semantic proximity Read

Mendelian randomization for autoimmune diseases: exploring causal links and drug targets in plasma proteomeSemantic proximity Read

Genomic atlas of 7,000 plasma proteins and their associations with diseases and traits in East Asian populationsSemantic proximity Read

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read

Plasma protein prioritisation in rheumatoid arthritis reveals druggable targets and shared biology with cardiovascular diseasesSemantic proximity Read

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participantsSemantic proximity Read

Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteinsSemantic proximity Read