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Article

Indian-enriched genetic variants are associated with cognitive function.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Abu-Amara Hasan, Zhao Wei, Li Zheng, Leung Yuk Yee, Schellenberg Gerard D, Wang Li-San, Dey Aparajit B, Dey Sharmistha, Zhou Xiang, Gross Alden L, Lee Jinkook, Kardia Sharon L R, Smith Jennifer A

Abstract excerpt

INTRODUCTION: Little is known about genetic risk factors for dementia in South Asians. Examining genetic variants that occur at higher frequency in India compared to other ancestries (i.e., Indian enriched variants) may identify genetic associations with cognitive function that are potentially unique to the Indian population. METHODS: We examined whether 3.43 million variants enriched in India compared to...

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PMID: 41612616
DOI: 10.1002/alz.71115
PMCID: PMC12855625

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