Article

Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from India

2024-08-10

Abstract excerpt

<title>Abstract</title> <p>The prevalence of dementia among South Asians across India is approximately 7.4% in those 60 years and older, yet little is known about genetic risk factors for dementia in this population. Most known risk loci for Alzheimer’s disease (AD) have been identified from studies conducted in European Ancestry (EA) but are unknown in South Asians. Using whole-genome sequence data from 2680 par...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4da6eef-32af-5333-9874-1d5dd7dc5c04
DOI: 10.21203/rs.3.rs-4712660/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from IndiaDOI 10.21203/rs.3.rs-4712660/v1Read

Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from IndiaSemantic proximity Read

Indian-enriched genetic variants are associated with cognitive function.Semantic proximity Read

Polygenic Risk Scores for Alzheimer's Disease and General Cognitive Function Are Associated With Measures of Cognition in Older South Asians.Semantic proximity Read

Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia.Semantic proximity Read

Exome sequencing identifies<i>ABCA7</i>as an important gene for familial AD cases from Eastern IndiaSemantic proximity Read

A reference panel for linkage disequilibrium and genotype imputation using whole-genome sequencing data from 2,680 participants across IndiaSemantic proximity Read

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementiaSemantic proximity Read

Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).Semantic proximity Read

APOE4 Allele Frequencies Show Dramatic Variation Across Indian PopulationsSemantic proximity Read

Mutation burden profile in familial Alzheimer's disease cases from India.Semantic proximity Read

The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case–control study in the Chinese populationSemantic proximity Read

Translating Alzheimer's disease–associated polymorphisms into functional candidates: a survey of IGAP genes and SNPsSemantic proximity Read