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Article

Genome-wide study links cardiometabolic factors to cognition via APOA4-APOA5-ZPR1-BUD13 and other loci in rural Indians.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025

Chakraborty Shreya, Subramanian Krithika, Rajesh Akkshaya, Majumder Rupanwita, Rupanagudi Khader Valli, Mensegere Abhishek, Issac Thomas Gregor, Sundarakumar Jonas, Kahali Bratati

Abstract excerpt

INTRODUCTION: Cardiometabolic risks affect cognition during aging, yet genetic basis for both remain understudied in Indians. METHODS: This study constructs an ancestry-matched Indian haplotype reference panel for genotype imputation of 5111 rural Indians. Single-locus, gene-based, conditional genome-wide association analyses are performed on 20 cognitive and 10 cardiometabolic traits, with subsequent follow-up...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40665476
DOI: 10.1002/alz.70429
PMCID: PMC12263347

Genes

APOA5
ZPR1
APOA4
BUD13
APOC3
TG
AMIGO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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