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Article

Kinetic Traps in RNA Folding: Targeted Design of Frameshifting Element Mutants by Thermodynamic and Kinetic Analysis of the Chikungunya Virus.

The journal of physical chemistry. B - 12 Feb 2026

Lee Samuel, Schlick Tamar

Abstract excerpt

Chikungunya virus (CHIKV) employs a programmed ribosomal frameshifting element (FSE) to regulate the synthesis of its viral proteins, making the FSE an attractive antiviral target. Yet the structural dynamics that govern its function are complex and poorly understood, with multiple folds discovered. Through computational analysis, we suggest that the FSE's conformation is determined by a competition between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41608886
DOI: 10.1021/acs.jpcb.5c08223
PMCID: PMC12908123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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