Loss of serotonergic function in carriers of PRKN mutations: a [11C]DASB PET study.

doi:10.1007/s00259-025-07693-2

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Article

Loss of serotonergic function in carriers of PRKN mutations: a [11C]DASB PET study.

European journal of nuclear medicine and molecular imaging - 1 May 2026

de Natale Edoardo Rosario, Wilson Heather, Verghese Joji P, Mulroy Eoin, Antoniadis Savvas, Terry Alana, Cavallieri Francesco, Avenali Micol, Nigro Pasquale, Valotassiou Varvara, Rabiner Eugenii A, Mullin Stephen, Tambasco Nicola, Pellecchia Maria Teresa, Xiromerisiou Georgia, Marshall Vicky L, Sammler Esther, Valente Enza Maria, Valzania Franco, Bhatia Kailash P, Politis Marios

Abstract excerpt

PURPOSE: We investigated serotonergic and dopaminergic terminal integrity role in PRKN-associated Parkinsonism (PRKN-PD) using [¹¹C]DASB Positron Emission Tomography (PET) and [¹²³I]FP-CIT Single Photon Emission Computerised Tomography (SPECT). METHODS: Fourteen PRKN-PD patients (mean age 49.70 ± 10.83, disease duration 10.95 ± 7.59 years, H&Y 2.0 ± 0.68), and twelve iPD patients (mean age 65.40 ± 7.48 years,...

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PMID: 41606302
DOI: 10.1007/s00259-025-07693-2
PMCID: PMC13121179

Genes

PRKN
CIT

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