Article
A multitracer dopaminergic PET study of young-onset parkinsonian patients with and without parkin gene mutations.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Aug 2009
Ribeiro Maria-João, Thobois Stéphane, Lohmann Ebba, du Montcel Sophie Tezenas, Lesage Suzanne, Pelissolo Antoine, Dubois Bruno, Mallet Luc, Pollak Pierre, Agid Yves, Broussolle Emmanuel, Brice Alexis, Remy Philippe
Abstract excerpt
UNLABELLED: The impact of parkin gene mutations on nigrostriatal dopaminergic degeneration is not well established. The purpose of this study was to characterize by PET using (18)F-fluoro-l-3,4-dihydroxyphenylalanine ((18)F-fluoro-l-DOPA), (11)C-PE2I, and (11)C-raclopride the pattern of dopaminergic lesions in young-onset Parkinson disease (YOPD) patients with or without mutations of the parkin gene and to...
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