Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster.

Cells - 5 May 2022

Zárate Rafaella V, Hidalgo Sergio, Navarro Nicole, Molina-Mateo Daniela, Arancibia Duxan, Rojo-Cortés Francisca, Oliva Carlos, Andrés María Estela, Zamorano Pedro, Campusano Jorge M

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease characterized by motor symptoms and dopaminergic cell loss. A pre-symptomatic phase characterized by non-motor symptoms precedes the onset of motor alterations. Two recent PET studies in human carriers of mutations associated with familial PD demonstrate an early serotonergic commitment-alteration in SERT binding-before any dopaminergic or motor dysfunction,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Neurodegenerative Diseases

Share to Parkinson Disease

Share to Protein Kinases

Share to Serotonin Plasma Membrane Transport Proteins

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 35563850
DOI: 10.3390/cells11091544
PMCID: PMC9105628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster.PMID 35563850Read ↗

Big Lessons from Tiny Flies:<em> Drosophila Melanogaster </em>as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter SystemsSemantic proximity Read ↗

Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors.Semantic proximity Read ↗

Loss of serotonergic function in carriers of PRKN mutations: a [11C]DASB PET study.Semantic proximity Read ↗

FUS-linked essential tremor associated with motor dysfunction in Drosophila.Semantic proximity Read ↗

Early nigrostriatal synaptic dysfunction underlies prodromal non-motor symptoms preceding dopaminergic neurodegeneration in an MPTP mouse model of Parkinson’s diseaseSemantic proximity Read ↗

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity.Semantic proximity Read ↗

Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.Semantic proximity Read ↗

In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study.Semantic proximity Read ↗

Genetic and biochemical changes of the serotonergic system in migraine pathobiology.Semantic proximity Read ↗

The serotonin transporter in Alzheimer's and Parkinson's disease.Semantic proximity Read ↗

Reduced platelet 5-HT content is associated with rest tremor in Parkinson's disease.Semantic proximity Read ↗

The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.