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Article

Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample.

HLA - 1 Oct 2022

Oliveira Maria Luiza Guimarães, Castelli Erick C, Veiga-Castelli Luciana C, Pereira Alison Luis E, Marcorin Letícia, Carratto Thássia M T, Souza Andreia S, Andrade Heloisa S, Simões Aguinaldo L, Donadi Eduardo A, Courtin David, Sabbagh Audrey, Giuliatti Silvana, Mendes-Junior Celso Teixeira

Abstract excerpt

Leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB1 and LILRB2 may play a pivotal role in maintaining self-tolerance and modulating the immune response through interaction with classical and nonclassical HLA molecules. Although both diversity and natural selection patterns over HLA genes have been extensively evaluated, little information is available concerning the genetic diversity and selection...

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PMID: 35754199
DOI: 10.1111/tan.14725

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