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The Coronavirus helicase in replication

31 May 2024

Abstract excerpt

The coronavirus nonstructural protein (nsp) 13 encodes an RNA helicase (nsp13-HEL) with multiple enzymatic functions, including unwinding and nucleoside phosphatase (NTPase) activities. Attempts for enzymatic inactivation have defined the nsp13-HEL as a critical enzyme for viral replication and a high-priority target for antiviral development. Helicases have been shown to play numerous roles beyond their...

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PMID: 38796132
DOI: 10.1016/j.virusres.2024.199401

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