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Article

Stabilization of elongated polyglutamine tracts by a helical peptide derived from N-terminal huntingtin.

IUBMB life - 1 Jul 2020

Sethi Ratnika, Roy Ipsita

Abstract excerpt

In Huntington's disease, the length of the polyglutamine tract in the mutant protein correlates positively with the formation of aggregates and disease symptoms and severity of the disease. Some disease-modifying factors exist. However, no organized study has been carried out to investigate the effect of polyglutamine length in the mutant protein on the efficacy of a therapeutic strategy. We had shown earlier...

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PMID: 32320524
DOI: 10.1002/iub.2288

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