Article
Tau/DDX6 interaction increases microRNA activity.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Aug 2018
Chauderlier Alban, Gilles Melissa, Spolcova Andrea, Caillierez Raphaelle, Chwastyniak Maggy, Kress Michel, Drobecq Herve, Bonnefoy Eliette, Pinet Florence, Weil Dominique, Buée Luc, Galas Marie-Christine, Lefebvre Bruno
Abstract excerpt
Tauopathies, such as Alzheimer's disease, are characterized by intracellular aggregates of insoluble Tau proteins. Originally described as a microtubule binding protein, recent studies demonstrated additional physiological roles for Tau. The fact that a single protein can regulate multiple cellular functions has posed challenge in terms of understanding mechanistic cues behind the pathology. Here, we used...
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