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Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics.

mBio - 11 May 2021

Dai Meiling, Du Wenjuan, Martínez-Romero Carles, Leenders Tim, Wennekes Tom, Rimmelzwaan Guus F, van Kuppeveld Frank J M, Fouchier Ron A M, Garcia-Sastre Adolfo, de Vries Erik, de Haan Cornelis A M

Abstract excerpt

The influenza A virus (IAV) neuraminidase (NA) is essential for virion release from cells and decoy receptors and an important target of antiviral drugs and antibodies. Adaptation to a new host sialome and escape from the host immune system are forces driving the selection of mutations in the NA gene. Phylogenetic analysis shows that until 2015, 16 amino acid substitutions in NA became fixed in the virus...

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Identifiers

PMID: 33975931
DOI: 10.1128/mBio.00287-21
PMCID: PMC8262965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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