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Article

Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation.

Genes & development - 1 Apr 2026

Samajdar Aniruddha, Amato Roberta, Jo Seongmoon, Cordes Ethan, Tai Albert, Raffa Grazia Daniela, Batista Luis F Z

Abstract excerpt

Mutations that impact maturation of human telomerase RNA (hTR) are common in telomere biology disorders. Here, we describe sequential posttranscriptional modifications that coordinate hTR biogenesis and decay. Initially, TGS1-mediated 5'-cap trimethylation targets long genomically extended hTR precursors for degradation. Prevention of 5'-cap trimethylation results in accumulation of nucleolar 3'-end extended...

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Share to Exosome Multienzyme Ribonuclease Complex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41571462
DOI: 10.1101/gad.353100.125
PMCID: PMC13041540

Genes

TGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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