Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Telomerase RNA Processing and Quality Control

25 Nov 2015

Abstract excerpt

The non-coding RNA subunit of telomerase provides the template for telomerase activity. In diverse fungi, 3' end processing of telomerase RNA involves a single cleavage by the spliceosome. Here, we examine how human telomerase RNA (hTR) primary transcripts are processed into the mature form of precisely 451 nt. We find that the splicing inhibitor isoginkgetin mimics the effects of RNA exosome inhibition and...

Topics

Join the communities discussing this publication.

Advanced biosensing and bioanalysis techniques
RNA Interference and Gene Delivery
Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26628367
DOI: 10.1016/j.celrep.2015.10.075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Telomerase RNA Processing and Quality ControlPMID 26628367Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation.Semantic proximity Read ↗

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNASemantic proximity Read ↗

Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs.Semantic proximity Read ↗

Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease.Semantic proximity Read ↗

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.Semantic proximity Read ↗

Regulation of human telomerase RNA biogenesis and localization.Semantic proximity Read ↗

Telomerase RNA biosynthesis and processingSemantic proximity Read ↗

Telomere biology disorders: time for moving towards the clinic?Semantic proximity Read ↗

Spliceosomal cleavage generates the 3′ end of telomerase RNASemantic proximity Read ↗

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere SynthesisSemantic proximity Read ↗

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled <i>In Vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.