Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease.

The Journal of clinical investigation - 1 Sept 2016

Boyraz Baris, Moon Diane H, Segal Matthew, Muosieyiri Maud Z, Aykanat Asli, Tai Albert K, Cahan Patrick, Agarwal Suneet

Abstract excerpt

The telomerase RNA component (TERC) is a critical determinant of cellular self-renewal. Poly(A)-specific ribonuclease (PARN) is required for posttranscriptional maturation of TERC. PARN mutations lead to incomplete 3' end processing and increased destruction of nascent TERC RNA transcripts, resulting in telomerase deficiency and telomere diseases. Here, we determined that overexpression of TERC increased telomere...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dyskeratosis Congenita
Share to Exoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lentivirus

Share to Protein Processing, Post-Translational

Share to RNA Nucleotidyltransferases

Share to RNA, Small Interfering

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 27482890
DOI: 10.1172/JCI87547
PMCID: PMC5004950

Genes

PARN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease.PMID 27482890Read ↗

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.Semantic proximity Read ↗

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNASemantic proximity Read ↗

Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation.Semantic proximity Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenitaSemantic proximity Read ↗

Human Telomerase RNA Processing and Quality ControlSemantic proximity Read ↗

Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complexSemantic proximity Read ↗

Telomere biology disorders: time for moving towards the clinic?Semantic proximity Read ↗

PARN Modulates Y RNA Stability and Its 3'-End Formation.Semantic proximity Read ↗

Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out modelsSemantic proximity Read ↗

Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita.Semantic proximity Read ↗

TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.