Article
Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs.
Molecular cell - 1 May 2003
Fu Dragony, Collins Kathleen
Abstract excerpt
Functional RNAs are processed according to cues from precursor expression context. The presence of an H/ACA motif within the human telomerase RNA (hTR) suggested that telomerase might utilize the biogenesis pathway of an H/ACA small nucleolar RNA. Here, we have investigated the requirements for processing, stability, and function of hTR. Instead of a biogenesis pathway dependent on transcription context or...
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