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Article

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation.

Cell reports - 4 Feb 2020

Chen Lu, Roake Caitlin M, Galati Alessandra, Bavasso Francesca, Micheli Emanuela, Saggio Isabella, Schoeftner Stefan, Cacchione Stefano, Gatti Maurizio, Artandi Steven E, Raffa Grazia D

Abstract excerpt

Biogenesis of the human telomerase RNA (hTR) involves a complex series of posttranscriptional modifications, including hypermethylation of the 5' mono-methylguanosine cap to a tri-methylguanosine cap (TMG). How the TMG cap affects hTR maturation is unknown. Here, we show that depletion of trimethylguanosine synthase 1 (TGS1), the enzyme responsible for cap hypermethylation, increases levels of hTR and telomerase....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32023455
DOI: 10.1016/j.celrep.2020.01.004
PMCID: PMC7156301

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