Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.

Abstract excerpt

The cyclin-dependent kinase subunit CKS remains poorly understood. We found that Caenorhabditis elegans CKS-1 and its partner CDK-1 co-localized to the cytosol, chromosomes, and spindle structures throughout cell division. Nevertheless, CKS-1 was required well after CDK-1, during oocyte meiosis I metaphase, which was prolonged in cks-1 mutants. Anaphase A precedes anaphase B in C. elegans oocytes, and while...

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• Anaphase
• CDC2-CDC28 Kinases
• CDC2 Protein Kinase
• Cyclin B
• Cyclin B1
• Cyclin-Dependent Kinases