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Article

HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.

Development (Cambridge, England) - 1 May 2013

Wang Ruishan, Kaul Zeenia, Ambardekar Charuta, Yamamoto Takaharu G, Kavdia Kanisha, Kodali Kiran, High Anthony A, Kitagawa Risa

Abstract excerpt

The anaphase inhibitor securin plays a crucial role in regulating the timing of sister chromatid separation during mitosis. When sister chromatid pairs become bioriented, the E3 ligase anaphase promoting complex/cyclosome (APC/C) ubiquitylates securin for proteolysis, triggering sister chromatid separation. Securin is also implicated in regulating meiotic progression. Securin protein levels change sharply during...

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PMID: 23578927
DOI: 10.1242/dev.090688

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APC
UBC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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