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Article

Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.

Science (New York, N.Y.) - 25 Apr 2003

Spruck Charles H, de Miguel Maria P, Smith Adrian P L, Ryan Aimee, Stein Paula, Schultz Richard M, Lincoln A Jeannine, Donovan Peter J, Reed Steven I

Abstract excerpt

We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdk1-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in both sexes. Sterility is due to failure of both male and female germ cells to progress past the first meiotic metaphase. The chromosomal even...

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Source

Identifiers

PMID: 12714746
DOI: 10.1126/science.1084149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12714746-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.PMID 12714746Read ↗

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Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombinationSemantic proximity Read ↗

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