Article
Dynamic signature of activity-stability tradeoff in lactamase evolution.
Nature communications - 21 Jan 2026
Arcia Ernesto, Keramisanou Dimitra, Jacobs Lian M C, Parker McKenna, Delgado Julián M, Kumar Mv Vasantha, Varma Sameer, Abzalimov Rinat, Chen Yu, Gelis Ioannis
Abstract excerpt
Our ability to understand protein evolution hinges on understanding how evolutionary landscapes are shaped at the fundamental protein level. Using TEM-1 β-lactamase we show that molecular traits related to the statistical ensemble nature of protein structure contribute to broader substrate specificity, active site-scaffold communication, and the selection of stabilizing substitutions. During the evolution of...
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