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Article

Sequence-function-stability relationships in proteins from datasets of functionally annotated variants: the case of TEM β-lactamases.

FEBS letters - 21 Sept 2012

Abriata Luciano A, Salverda Merijn L M, Tomatis Pablo E

Abstract excerpt

A dataset of TEM lactamase variants with different substrate and inhibition profiles was compiled and analyzed. Trends show that loops are the main evolvable regions in these enzymes, gradually accumulating mutations to generate increasingly complex functions. Notably, many mutations present in evolved enzymes are also found in simpler variants, probably originating functional promiscuity. Following a...

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Identifiers

PMID: 22850115
DOI: 10.1016/j.febslet.2012.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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