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Different Mi-2 Complexes for Various Developmental Functions in Caenorhabditis elegans

27 Oct 2010

Abstract excerpt

Biochemical purifications from mammalian cells and Xenopus oocytes revealed that vertebrate Mi-2 proteins reside in multisubunit NuRD (Nucleosome Remodeling and Deacetylase) complexes. Since all NuRD subunits are highly conserved in the genomes of C. elegans and Drosophila, it was suggested that NuRD complexes also exist in invertebrates. Recently, a novel dMec complex, composed of dMi-2 and dMEP-1 was identified...

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PMID: 21060680
DOI: 10.1371/journal.pone.0013681

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