Article
Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.
American journal of respiratory cell and molecular biology - 1 Nov 2013
Gill Sean E, Gharib Sina A, Bench Eli M, Sussman Samuel W, Wang Roy T, Rims Cliff, Birkland Timothy P, Wang Ying, Manicone Anne M, McGuire John K, Parks William C
Abstract excerpt
Tissue inhibitor of metalloproteinases-3 (TIMP-3) has emerged as a key mediator of inflammation. Recently, we reported that the resolution of inflammation is impaired in Timp3(-/-) mice after bleomycin-induced lung injury. Here, we demonstrate that after LPS instillation (another model of acute lung injury), Timp3(-/-) mice demonstrate enhanced and persistent neutrophilia, increased numbers of infiltrated...
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