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Article

Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching.

Journal of advanced research - 1 May 2025

Tang Zhenquan, Xie Jingfang, Jin Ming, Wei Guoquan, Fu Ziwei, Luo Xiajing, Li Chuling, Jia Xiaoqian, Zheng Hao, Zhong Lintao, Li Xinzhong, Wang Junfen, Chen Guojun, Chen Yanmei, Liao Wangjun, Liao Yulin, Bin Jianping, Huang Senlin

Abstract excerpt

INTRODUCTION: Sympathetic hyperinnervation plays an important role in modulating the vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in abdominal aortic aneurysm (AAA) is still unknown. OBJECTIVES: This study aimed to investigate the role of sympathetic hyperinnervation in promoting AAA development and the underlying mechanism involved. METHODS: Western blotting and immunochemical...

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Share to Adenosine Triphosphate
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Abdominal

Share to Mice, Knockout

Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 38821358
DOI: 10.1016/j.jare.2024.05.028
PMCID: PMC12126710

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