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Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal.

Biological psychiatry - 1 Jan 2021

Uffelmann Emil, Posthuma Danielle

Abstract excerpt

Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal genetic variants that span much of the genome. This widespread polygenicity complicates biological understanding because no single variant can explain disease etiology. A strategy to advance biological insight is to seek convergent functions among the large set of variants and map them to a smaller set of...

Topics

Genetic Predisposition to Disease
Genome
Genome-Wide Association Study
Genomics
Humans
Multifactorial Inheritance
Phenotype
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32736792
DOI: 10.1016/j.biopsych.2020.05.022

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