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Article

Multi-Ancestry Mendelian Randomization Reveals Lipid-Associated Genetic Risk Factors for COPD.

International journal of chronic obstructive pulmonary disease - 1 Jan 2025

Wu Hailan, Li Huan, Tang Weiwei, Di Yicheng, Zhu Yingran, Dai Wei, Zhao Ming

Abstract excerpt

Background: Previous Mendelian randomization (MR) studies investigating the causal relationship between lipid traits and chronic obstructive pulmonary disease (COPD) have primarily focused on individuals of European (EUR) ancestry, limiting the generalizability of findings. This study aimed to address this limitation. Methods: Summary-level data for individuals of East Asian (EAS), African (AFR), and Hispanic...

Topics

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Black People
Cholesterol, HDL
Cholesterol, LDL
Dyslipidemias
East Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hispanic or Latino

Pulmonary Disease, Chronic Obstructive

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Open in PubMed Open full text

Identifiers

PMID: 40901574
DOI: 10.2147/COPD.S532361
PMCID: PMC12399851

Genes

TG
MAML2
MVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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