Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity in the association of genetic risk for RA and resultant RA phenotypes.

Rheumatology (Oxford, England) - 4 Feb 2026

Riley Thomas R, Wheeler Austin M, England Bryant R, Cannon Grant W, Sauer Brian, Kunkel Gary A, Wysham Katherine D, Wallace Beth I, Monach Paul A, Reimold Andreas, Kerr Gail S, Smith Isaac D, Richards John Steuart, Lee Iris, Thiele Geoffrey M, Xiao Rui, Damrauer Scott M, Levin Michael G, George Michael D, Mikuls Ted R, Baker Joshua F

Abstract excerpt

OBJECTIVES: The impact of the genetic risk for RA on resultant disease phenotype in RA is incompletely understood. Using individual genetic variants associated with RA and a polygenic score (PGS), we hypothesized that those with higher genetic risk for RA would demonstrate a more severe disease course. METHODS: We genotyped participants from the Veterans Affairs RA registry (VARA), a prospective cohort of RA. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Risk Score

Share to HLA-DRB1 Chains

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Registries

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 41548231
DOI: 10.1093/rheumatology/keag029
PMCID: PMC13078286

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity in the association of genetic risk for RA and resultant RA phenotypes.PMID 41548231Read ↗

Genetics of rheumatoid arthritis susceptibility, severity, and treatment response.Semantic proximity Read ↗

Identifying shared genetic architecture between rheumatoid arthritis and other conditions: a phenome-wide association study with genetic risk scores.Semantic proximity Read ↗

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.Semantic proximity Read ↗

The genetic architecture of rheumatoid arthritis: from susceptibility to clinical subphenotype associations.Semantic proximity Read ↗

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.Semantic proximity Read ↗

Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes.Semantic proximity Read ↗

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?Semantic proximity Read ↗

Utility of polygenic risk scores to aid in the diagnosis of rheumatic diseases.Semantic proximity Read ↗

Role of Selected Genetic Polymorphisms in the Development of Rheumatoid Arthritis in a British White Population.Semantic proximity Read ↗

Recent advances in the genetics of RA susceptibility.Semantic proximity Read ↗

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.Semantic proximity Read ↗

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.