Enhancing the heat tolerance of homolactic Escherichia coli through reverse metabolic engineering.

Abstract excerpt

Improving Escherichia coli's thermotolerance through rational engineering is hindered by limited knowledge of the molecular mechanisms involved in supraoptimal thermal adaptation. To address this issue, we applied a reverse metabolic engineering strategy to develop a D-homolactic E. coli strain under non-aerated conditions. We first characterized the thermal reaction norms of the kinetic and stoichiometric...

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