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Genetic Mutations That Drive Evolutionary Rescue to Lethal Temperature in Escherichia coli.

Genome biology and evolution - 3 Nov 2020

Batarseh Tiffany N, Hug Shaun M, Batarseh Sarah N, Gaut Brandon S

Abstract excerpt

Evolutionary rescue occurs when adaptation restores population growth against a lethal stressor. Here, we studied evolutionary rescue by conducting experiments with Escherichia coli at the lethal temperature of 43.0 °C, to determine the adaptive mutations that drive rescue and to investigate their effects on fitness and gene expression. From hundreds of populations, we observed that ∼9% were rescued by genetic...

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Identifiers

PMID: 32785667
DOI: 10.1093/gbe/evaa174
PMCID: PMC7750951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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