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Article

ARF6 controls VSMC phenotypic switching upon lipid stimulation to promote inflammatory signaling contributing to the progression of atherosclerosis.

The Journal of biological chemistry - 1 Mar 2026

Fiola-Masson Émilie, Campbell Shirley, Laplante Véronique, Lejri Rania, Kanaho Yasunori, Gauchat Jean-François, Servant Marc J, Claing Audrey

Abstract excerpt

Vascular smooth muscle cells (VSMCs) play a pivotal role in the development and progression of atherosclerosis. Traditionally viewed as contractile cells that maintain vascular tone and structure, VSMCs undergo phenotypic switching in response to atherogenic stimuli, such as high circulating levels of LDL, thus adopting synthetic, osteogenic, or macrophage-like phenotypes. This plasticity contributes to plaque...

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Identifiers

PMID: 41539563
DOI: 10.1016/j.jbc.2026.111165
PMCID: PMC12876588

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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