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Article

Advances in the pathogenesis of FLT3 -mutated acute myeloid leukemia and targeted treatments.

Current opinion in oncology - 1 Nov 2024

Travaglini Serena, Gurnari Carmelo, Ottone Tiziana, Voso Maria Teresa

Abstract excerpt

PURPOSE OF REVIEW: FLT3 mutations are among the most common myeloid drivers identified in adult acute myeloid leukemia (AML). Their identification is crucial for the precise risk assessment because of the strong prognostic significance of the most recurrent type of FLT3 alterations, namely internal tandem duplications (ITDs). Recent advances in the pathogenesis and biology of FLT3 -mutated AML have opened an...

Topics

Humans
fms-Like Tyrosine Kinase 3
Leukemia, Myeloid, Acute
Mutation
Molecular Targeted Therapy
Protein Kinase Inhibitors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39246183
DOI: 10.1097/CCO.0000000000001094
PMCID: PMC11460763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39246183-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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