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Article

FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML.

Scientific reports - 7 Dec 2021

Kivioja Jarno, Malani Disha, Kumar Ashwini, Kontro Mika, Parsons Alun, Kallioniemi Olli, Heckman Caroline A

Abstract excerpt

FLT3 internal tandem duplication (FLT3-ITD) is a frequent mutation in acute myeloid leukemia (AML) and remains a strong prognostic factor due to high rate of disease recurrence. Several FLT3-targeted agents have been developed, but determinants of variable responses to these agents remain understudied. Here, we investigated the role FLT3-ITD allelic ratio (ITD-AR), ITD length, and associated gene expression...

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Identifiers

PMID: 34876631
DOI: 10.1038/s41598-021-03010-7
PMCID: PMC8651734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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