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Article

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.

The Journal of cell biology - 3 Apr 2017

Yasuda Kyota, Clatterbuck-Soper Sarah F, Jackrel Meredith E, Shorter James, Mili Stavroula

Abstract excerpt

Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneless ribonucleoprotein compartment. Formation of FUS inclusions is promoted by amyotrophic lateral sclerosis (ALS)-linked mutations, but the cellular functions affected upon inclusion formation are poorly defined. In this study, we find that FUS inclusions lead to the mislocalization of specific RNAs from...

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Source

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Identifiers

PMID: 28298410
DOI: 10.1083/jcb.201608022
PMCID: PMC5379945

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.PMID 28298410Read ↗

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