Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.

doi:10.1093/jnci/djt303

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Article

Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.

Journal of the National Cancer Institute - 20 Nov 2013

Ek Weronica E, Levine David M, D'Amato Mauro, Pedersen Nancy L, Magnusson Patrik K E, Bresso Francesca, Onstad Lynn E, Schmidt Peter T, Törnblom Hans, Nordenstedt Helena, Romero Yvonne, Chow Wong-Ho, Murray Liam J, Gammon Marilie D, Liu Geoffrey, Bernstein Leslie, Casson Alan G, Risch Harvey A, Shaheen Nicholas J, Bird Nigel C, Reid Brian J, Corley Douglas A, Hardie Laura J, Ye Weimin, Wu Anna H, Zucchelli Marco, Spector Tim D, Hysi Pirro, Vaughan Thomas L, Whiteman David C, MacGregor Stuart

Abstract excerpt

BACKGROUND: Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA, and every year 0.12% to 0.5% of BE patients progress to EA. BE typically arises on a background of chronic gastroesophageal reflux (GERD), one of the risk factors for EA. METHODS: We used genome-wide association data to investigate the genetic architecture...

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Identifiers

PMID: 24168968
DOI: 10.1093/jnci/djt303
PMCID: PMC3833931

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Source receipt: pubmed, retrieved 7 Sept 2026.

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