Article
Identification of loci of functional relevance to Barrett's esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data.
PloS one - 1 Jan 2019
Schröder Julia, Schüller Vitalia, May Andrea, Gerges Christian, Anders Mario, Becker Jessica, Hess Timo, Kreuser Nicole, Thieme René, Ludwig Kerstin U, Noder Tania, Venerito Marino, Veits Lothar, Schmidt Thomas, Fuchs Claudia, Izbicki Jakob R, Hölscher Arnulf H, Dakkak Dani, Jansen-Winkeln Boris, Moulla Yusef, Lyros Orestis, Niebisch Stefan, Mehdorn Matthias, Lang Hauke, Lorenz Dietmar, Schumacher Brigitte, Mayershofer Rupert, Vashist Yogesh, Ott Katja, Vieth Michael, Weismüller Josef, Mangold Elisabeth, Nöthen Markus M, Moebus Susanne, Knapp Michael, Neuhaus Horst, Rösch Thomas, Ell Christian, Gockel Ines, Schumacher Johannes, Böhmer Anne C
Abstract excerpt
Esophageal adenocarcinoma (EA) and its precancerous condition Barrett's esophagus (BE) are multifactorial diseases with rising prevalence rates in Western populations. A recent meta-analysis of genome-wide association studies (GWAS) data identified 14 BE/EA risk loci located in non-coding genomic regions. Knowledge about the impact of non-coding variation on disease pathology is incomplete and needs further...
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