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Article

Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2015

Link Jenny C, Chen Xuqi, Prien Christopher, Borja Mark S, Hammerson Bradley, Oda Michael N, Arnold Arthur P, Reue Karen

Abstract excerpt

OBJECTIVE: The molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels. APPROACH AND RESULTS: We assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the four core genotypes mouse model (XX females, XX males, XY females, and XY males). In gonadally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26112012
DOI: 10.1161/ATVBAHA.115.305460
PMCID: PMC4668127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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