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Article

Quantitative analysis of in vivo initiator selection by yeast RNA polymerase II supports a scanning model.

The Journal of biological chemistry - 19 May 2006

Kuehner Jason N, Brow David A

Abstract excerpt

Initiation of transcription by RNA polymerase II (RNAP II) on Saccharomyces cerevisiae messenger RNA (mRNA) genes typically occurs at multiple sites 40-120 bp downstream of the TATA box. The mechanism that accommodates this extended and variable promoter architecture is unknown, but one model suggests that RNAP II forms an open promoter complex near the TATA box and then scans the template DNA strand for start...

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PMID: 16571719
DOI: 10.1074/jbc.M601937200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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