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Article

Impact of AKR1C2 and AKR1C3 single-nucleotide polymorphism rs28571848 in adipose tissues of individuals with severe obesity.

American journal of physiology. Endocrinology and metabolism - 1 Mar 2026

Ostinelli Giada, Ramalho Alan, Gauthier Marie-Fréderique, Julien François, Biertho Laurent, Vohl Marie-Claude, Tchernof André

Abstract excerpt

Adipose tissue androgen turnover, dictated at least in part by the enzymes aldo-keto reductase 1 C type 2 (AKR1C2) and aldo-keto reductase 1 C type 3 (AKR1C3), has been linked to abdominal obesity. Recently, we investigated a single-nucleotide polymorphism (SNP) named rs28571858, that might increase AKR1C2 and AKR1C3 expression in human adipose tissue. Here, we studied the impact of rs28571848 on adipose tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to 3-Hydroxysteroid Dehydrogenases
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Source

Identifiers

PMID: 41500516
DOI: 10.1152/ajpendo.00512.2024

Genes

AKR1C3
AKR1C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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