Article
Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
PloS one - 4 Nov 2010
Wang Hairu, Wu Ming, Zhu Weiguang, Shen Jin, Shi Xiaoming, Yang Jie, Zhao Qihui, Ni Chuan, Xu Yaochu, Shen Hongbing, Shen Chong, Gu Harvest F
Abstract excerpt
BACKGROUND: AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we...
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