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Article

Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.

Frontiers in endocrinology - 1 Jan 2024

Wang Yan, Yang Chao, Wen Jun, Ju Lingling, Ren Zhengyun, Zhang Tongtong, Liu Yanjun

Abstract excerpt

Early-onset obesity is a rising health concern influenced by heredity. However, many monogenic obesity variants (MOVs) remain to be discovered due to differences in ethnicity and culture. Additionally, patients with known MOVs have shown limited weight loss after bariatric surgery, suggesting it can be used as a screening tool for new candidates. In this study, we performed whole-exome sequencing (WES) combined...

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Identifiers

PMID: 38469147
DOI: 10.3389/fendo.2024.1334342
PMCID: PMC10925648

Genes

CAMKK2
PCSK1

Variants

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