Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADAR1-Mediated RNA Editing, A Novel Mechanism Controlling Phenotypic Modulation of Vascular Smooth Muscle Cells.

Circulation research - 22 Jul 2016

Fei Jia, Cui Xiao-Bing, Wang Jia-Ning, Dong Kun, Chen Shi-You

Abstract excerpt

RATIONALE: Vascular smooth muscle cell (SMC) phenotypic modulation is characterized by the downregulation of SMC contractile genes. Platelet-derived growth factor-BB, a well-known stimulator of SMC phenotypic modulation, downregulates SMC genes via posttranscriptional regulation. The underlying mechanisms, however, remain largely unknown. OBJECTIVE: To establish RNA editing as a novel mechanism controlling SMC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to Double-Blind Method

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Rats, Sprague-Dawley

Share to RNA Editing

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 27199464
DOI: 10.1161/CIRCRESAHA.116.309003
PMCID: PMC4961590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAR1-Mediated RNA Editing, A Novel Mechanism Controlling Phenotypic Modulation of Vascular Smooth Muscle Cells.PMID 27199464Read ↗

Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders.Semantic proximity Read ↗

Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.Semantic proximity Read ↗

Smooth muscle expression of RNA editing enzyme <i>ADAR1</i> controls activation of RNA sensor MDA5 in atherosclerosisSemantic proximity Read ↗

CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.Semantic proximity Read ↗

Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease.Semantic proximity Read ↗

CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradationSemantic proximity Read ↗

Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin.Semantic proximity Read ↗

RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis.Semantic proximity Read ↗

m6A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway.Semantic proximity Read ↗

MicroRNA regulation of phenotypic transformations in vascular smooth muscle: relevance to vascular remodeling.Semantic proximity Read ↗

circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF.Semantic proximity Read ↗

MicroRNA‐26a is a novel regulator of vascular smooth muscle cell functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.