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Article

Reactive oxygen species-induced long intergenic noncoding RNA p21 accelerates abdominal aortic aneurysm formation by promoting secretary smooth muscle cell phenotypes.

Journal of molecular and cellular cardiology - 1 Jan 2023

Wang Shifei, Wang Junfen, Cai Donghua, Li Xinzhong, Zhong Lintao, He Xiang, Lin Zhongqiu, Lai Yanxian, Zheng Hao, Zhou Yilin, Xiao Zhiwen, Liao Wangjun, Liao Yulin, Xiu Jiancheng, Bin Jianping

Abstract excerpt

Whether long noncoding RNAs participate in the formation of abdominal aortic aneurysms (AAAs) through the regulation of SMC phenotypic switching is unknown. lincRNA-p21 induced by reactive oxygen species (ROS) is likely functionally associated with SMC phenotypic switching. We thus investigated the role of lincRNA-p21 in SMC phenotypic switching-associated AAA formation and its underlying mechanisms. An analysis...

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Share to Aortic Aneurysm, Abdominal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocytes, Smooth Muscle

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Identifiers

PMID: 36436251
DOI: 10.1016/j.yjmcc.2022.11.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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